Author: Carabineiro, Sónia Alexandra Correia
Title: Applications of Gold Nanoparticles in Nanomedicine: Recent Advances in Vaccines † Document date: 2017_5_22
ID: 0nz0qioh_32
Snippet: Gold nanoparticles obtained by a modified Turkevich method were functionalized with mucin-1 (MUC-1) glycoprotein using Clealand's reagent [82] . Other authors also reported on the synthesis of MUC1-glycopeptide antigens and their coupling to gold nanoparticles of different sizes and developed a new dot-blot immunoassay to test the potential antigen-antibody binding [58] . A glycopeptide sequence derived from MUC-1 glycoprotein and the T-cell epit.....
Document: Gold nanoparticles obtained by a modified Turkevich method were functionalized with mucin-1 (MUC-1) glycoprotein using Clealand's reagent [82] . Other authors also reported on the synthesis of MUC1-glycopeptide antigens and their coupling to gold nanoparticles of different sizes and developed a new dot-blot immunoassay to test the potential antigen-antibody binding [58] . A glycopeptide sequence derived from MUC-1 glycoprotein and the T-cell epitope P30 sequence were immobilized gold nanoparticles attached to polyethylene glycol chains [92] . After immunization, mice showed significant MHC-II mediated immune responses, and their antisera were able to recognize human MCF-7 breast cancer cells. Gold nanoparticles designed this way have the potential to be used in the development of anticancer vaccines.
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