Author: Gwon, Yong-Dae; Strand, Mårten; Lindqvist, Richard; Nilsson, Emma; Saleeb, Michael; Elofsson, Mikael; Överby, Anna K.; Evander, Magnus
Title: Antiviral Activity of Benzavir-2 against Emerging Flaviviruses Document date: 2020_3_22
ID: 0ym40eki_52
Snippet: We have previously discovered novel anti-adenoviral compounds, and a subsequent medicinal chemistry program resulted in benzavir-2 [17] , a potent broad-spectrum antiviral compound. Benzavir-2 presents potent antiviral activity against DNA-viruses (HAdV, HSV-1, and HSV-2, with respective acyclovir-resistant clinical HSV isolates), and recently we reported that benzavir-2 is active in vitro against a negative-sense single stranded RNA-virus, RVFV .....
Document: We have previously discovered novel anti-adenoviral compounds, and a subsequent medicinal chemistry program resulted in benzavir-2 [17] , a potent broad-spectrum antiviral compound. Benzavir-2 presents potent antiviral activity against DNA-viruses (HAdV, HSV-1, and HSV-2, with respective acyclovir-resistant clinical HSV isolates), and recently we reported that benzavir-2 is active in vitro against a negative-sense single stranded RNA-virus, RVFV [16, 18, 19] . Here, we describe the antiviral activity of benzavir-2 against positive-sense single-stranded RNA viruses from the flavivirus genus, together with the activity of three structural analogs to benzavir-2 and two commercial antiviral drugs with previously-reported anti-flavivirus activity [20, 35, 36] .
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