Selected article for: "anti activity and recombinant virus"
Author: Gwon, Yong-Dae; Strand, Mårten; Lindqvist, Richard; Nilsson, Emma; Saleeb, Michael; Elofsson, Mikael; Överby, Anna K.; Evander, Magnus
Title: Antiviral Activity of Benzavir-2 against Emerging Flaviviruses
  • Document date: 2020_3_22
    • ID: 0ym40eki_53
    Snippet: The recombinant ZIKV with ZsGreen-insertion (rZIKV-ZsGreen, Brazilian strain isolate) was a valuable screening tool. The infection was easily quantified and the infectivity of the recombinant virus was very similar to wt ZIKV [21] . We used this recombinant virus for primary assessment of the anti-ZIKV activity of benzavir-2. The dose-response studies revealed a sub-micromolar EC 50 value of 0.8 ± 0.1 µM for benzavir-2 (EC 90 value of 1.2 ± 0......
    Document: The recombinant ZIKV with ZsGreen-insertion (rZIKV-ZsGreen, Brazilian strain isolate) was a valuable screening tool. The infection was easily quantified and the infectivity of the recombinant virus was very similar to wt ZIKV [21] . We used this recombinant virus for primary assessment of the anti-ZIKV activity of benzavir-2. The dose-response studies revealed a sub-micromolar EC 50 value of 0.8 ± 0.1 µM for benzavir-2 (EC 90 value of 1.2 ± 0.3 µM), whereas the two commercial antiviral drugs, ribavirin and favipiravir, that were included as positive controls, had very moderate to no antiviral activity, respectively.

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