Author: Zhai, Xiaofeng; Wang, Shilei; Zhu, Mengyan; He, Wei; Pan, Zhongzhou; Su, Shuo
Title: Antiviral Effect of Lithium Chloride and Diammonium Glycyrrhizinate on Porcine Deltacoronavirus In Vitro Document date: 2019_9_9
ID: 1m5yr8uc_35
Snippet: We also found that LiCl and DG could inhibit LLC-PK1 cell apoptosis caused by PDCoV infection similarly to the results of a previous report [28] . Apoptosis is considered a host innate defense mechanism to eliminate virus-infected cells. However, some viruses use and trigger apoptosis to facilitate the release of viral progeny for further dissemination. This can be fundamental for viral pathogenesis and disease development to promote cell death a.....
Document: We also found that LiCl and DG could inhibit LLC-PK1 cell apoptosis caused by PDCoV infection similarly to the results of a previous report [28] . Apoptosis is considered a host innate defense mechanism to eliminate virus-infected cells. However, some viruses use and trigger apoptosis to facilitate the release of viral progeny for further dissemination. This can be fundamental for viral pathogenesis and disease development to promote cell death and tissue injury. Previous studies showed that PDCoV induces caspase-dependent apoptosis through the activation of the cytochrome c-mediated intrinsic mitochondrial pathway [38] . Whether LiCl and DG inhibit PDCoV-induced apoptosis through suppression of the cytochrome c-mediated intrinsic mitochondrial pathway needs to be further studied.
Search related documents:
Co phrase search for related documents- apoptosis trigger and viral progeny: 1
- caspase dependent apoptosis and previous study: 1
- caspase dependent apoptosis and viral pathogenesis: 1, 2
- caspase dependent apoptosis and viral progeny: 1, 2
- cell apoptosis and previous study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- cell apoptosis and tissue injury: 1, 2, 3, 4, 5, 6, 7, 8, 9
- cell apoptosis and viral pathogenesis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- cell apoptosis and viral progeny: 1, 2, 3, 4, 5, 6, 7
- cell death and previous study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- cell death and study need: 1
- cell death and tissue injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- cell death and tissue injury cell death: 1, 2, 3, 4, 5
- cell death and viral pathogenesis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell death and viral progeny: 1, 2, 3, 4, 5, 6, 7
- defense mechanism and previous study: 1
- defense mechanism and tissue injury: 1, 2
- defense mechanism and viral pathogenesis: 1, 2, 3
- defense mechanism and viral progeny: 1
- disease development and previous study: 1, 2, 3, 4, 5, 6, 7
Co phrase search for related documents, hyperlinks ordered by date