Selected article for: "cell apoptosis and mitochondrial pathway"
Author: Zhai, Xiaofeng; Wang, Shilei; Zhu, Mengyan; He, Wei; Pan, Zhongzhou; Su, Shuo
Title: Antiviral Effect of Lithium Chloride and Diammonium Glycyrrhizinate on Porcine Deltacoronavirus In Vitro
  • Document date: 2019_9_9
    • ID: 1m5yr8uc_35
    Snippet: We also found that LiCl and DG could inhibit LLC-PK1 cell apoptosis caused by PDCoV infection similarly to the results of a previous report [28] . Apoptosis is considered a host innate defense mechanism to eliminate virus-infected cells. However, some viruses use and trigger apoptosis to facilitate the release of viral progeny for further dissemination. This can be fundamental for viral pathogenesis and disease development to promote cell death a.....
    Document: We also found that LiCl and DG could inhibit LLC-PK1 cell apoptosis caused by PDCoV infection similarly to the results of a previous report [28] . Apoptosis is considered a host innate defense mechanism to eliminate virus-infected cells. However, some viruses use and trigger apoptosis to facilitate the release of viral progeny for further dissemination. This can be fundamental for viral pathogenesis and disease development to promote cell death and tissue injury. Previous studies showed that PDCoV induces caspase-dependent apoptosis through the activation of the cytochrome c-mediated intrinsic mitochondrial pathway [38] . Whether LiCl and DG inhibit PDCoV-induced apoptosis through suppression of the cytochrome c-mediated intrinsic mitochondrial pathway needs to be further studied.

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