Author: Soto-Rodriguez, Guadalupe; Gonzalez-Barrios, Juan-Antonio; Martinez-Fong, Daniel; Blanco-Alvarez, Victor-Manuel; Eguibar, Jose R.; Ugarte, Araceli; Martinez-Perez, Francisco; Brambila, Eduardo; Millán-Perez Peña, Lourdes; Pazos-Salazar, Nidia-Gary; Torres-Soto, Maricela; Garcia-Robles, Guadalupe; Tomas-Sanchez, Constantino; Leon-Chavez, Bertha Alicia
Title: Analysis of Chemokines and Receptors Expression Profile in the Myelin Mutant Taiep Rat Document date: 2015_3_25
ID: 0nb4laxz_24
Snippet: The 1-month-old taiep rat showed difference between mRNA and protein CXCR4 that might be due to two causes: (1) a decrease in stabilization of CXCR4 mRNA or an increase in CXCR4 protein translation that would rapidly consume CXCR4 mRNA [45] and (2) the increase of CXCR4 protein in the brainstem that could be due to the presence of other CXCR4 positive cells such as OPCs that are known to migrate from ventral ventricular zone during myelination, w.....
Document: The 1-month-old taiep rat showed difference between mRNA and protein CXCR4 that might be due to two causes: (1) a decrease in stabilization of CXCR4 mRNA or an increase in CXCR4 protein translation that would rapidly consume CXCR4 mRNA [45] and (2) the increase of CXCR4 protein in the brainstem that could be due to the presence of other CXCR4 positive cells such as OPCs that are known to migrate from ventral ventricular zone during myelination, which is still active at one month of age [46] . Supporting the latter suggestion is the finding that mRNA and protein CXCR4 are decreased in the brainstem of 6-month-old taiep rats, when the migration of OPCs was completed [47] .
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