Author: Wang, Kai; Ran, Ling; Yan, Tao; Niu, Zheng; Kan, Zifei; Zhang, Yiling; Yang, Yang; Xie, Luyi; Huang, Shilei; Yu, Qiuhan; Wu, Di; Song, Zhenhui
Title: Anti-TGEV Miller Strain Infection Effect of Lactobacillus plantarum Supernatant Based on the JAK-STAT1 Signaling Pathway Document date: 2019_11_6
ID: 05tf6oqa_3
Snippet: A strain of L. plantarum was successfully isolated and named Lp-1 (Song Han et al., 2017) . We wondered whether the IPEC-J2 cells treated by Lp-1 could induce an antiviral mechanism through the IFN-β/JAKs/STAT/ISGs pathway after TGEV infection. In the present study, we found that the supernatant of L. plantarum Lp-1 (Lp-1s) could significantly inhibit TGEV infection. By detecting the replication of TGEV N gene in porcine intestinal epithelial ce.....
Document: A strain of L. plantarum was successfully isolated and named Lp-1 (Song Han et al., 2017) . We wondered whether the IPEC-J2 cells treated by Lp-1 could induce an antiviral mechanism through the IFN-β/JAKs/STAT/ISGs pathway after TGEV infection. In the present study, we found that the supernatant of L. plantarum Lp-1 (Lp-1s) could significantly inhibit TGEV infection. By detecting the replication of TGEV N gene in porcine intestinal epithelial cells treated with Lp-1s at different time points, we confirmed that Lp-1s had a preventive effect against TGEV. Then, by detecting the levels of IFN, p-STAT and ISGs, we further confirmed that Lp-1s exerts its anti-TGEV role by upregulating the expression of IFN-β.
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