Applications of Gold Nanoparticles in Nanomedicine: Recent Advances in Vaccines †

Carabineiro, Sónia Alexandra Correia

Needle-free vaccine delivery systems efficiently transport powdered or particulate DNA and protein vaccines into the epidermal tissue [73] [74] [75] [76] . It can be used to directly transfect antigen presenting cells by formulating DNA or protein vaccines onto 1-3 µm gold particles (particle-mediated immunization). A solid-in-oil dispersion of gold nanorods can also enhance transdermal protein delivery and skin vaccination [77] . Plasmid DNA (pDNA)-coated gold nanoparticles were successfully delivered into ex vivo murine and porcine skin at low inlet pressures using parallel arrays of microchannels [78] . It was shown that full-length pDNA was preserved after each particle preparation and jetting procedures.