Selected article for: "genome sequence and high throughput"
Author: Barzon, Luisa; Lavezzo, Enrico; Militello, Valentina; Toppo, Stefano; Palù, Giorgio
Title: Applications of Next-Generation Sequencing Technologies to Diagnostic Virology
  • Document date: 2011_11_14
    • ID: 01nuj0lk_38
    Snippet: Deep sequencing showed also variability of herpes simplex virus 1 (HSV-1) genome and allowed to demonstrate virulence genes. Using Illumina high-throughput sequencing, genome sequences of both a laboratory strain (F) and a low-passage clinical isolate (H129) were obtained and compared with the available genome sequence of a more virulent isolate of HSV-1 (strain 17) [94] . The HSV-1 H129 strain, isolated from the brain of an encephalitic patient,.....
    Document: Deep sequencing showed also variability of herpes simplex virus 1 (HSV-1) genome and allowed to demonstrate virulence genes. Using Illumina high-throughput sequencing, genome sequences of both a laboratory strain (F) and a low-passage clinical isolate (H129) were obtained and compared with the available genome sequence of a more virulent isolate of HSV-1 (strain 17) [94] . The HSV-1 H129 strain, isolated from the brain of an encephalitic patient, is the only virus known to transit neural circuits exclusively in an anterograde direction [95] . Whole genome sequencing demonstrated many protein-coding variations between strains F and H129 and the genome reference strain 17 and some genes were proposed to be responsible of the anterograde mutant phenotype of strain H129, including the neurovirulence protein ICP34.5, while a frameshift mutation in the UL13 kinase could account for decreased neurovirulence of strain F [94] .

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