Author: Lin, Feng; Muthuraman, Kumar; Lawley, Mark
Title: An optimal control theory approach to non-pharmaceutical interventions Document date: 2010_2_19
ID: 0x294f8t_7
Snippet: In this work, we use an expanded SIR model to develop triggers for NPI implementation to minimize expected person-days lost resulting from influenza related deaths and NPI implementation. NPI policies are derived for a deterministic control model. Results are compared with the most relevant optimal control papers discussed above. Multivariate sensitivity analyses based on Latin Hypercube Sampling are performed to investigate the effects of input .....
Document: In this work, we use an expanded SIR model to develop triggers for NPI implementation to minimize expected person-days lost resulting from influenza related deaths and NPI implementation. NPI policies are derived for a deterministic control model. Results are compared with the most relevant optimal control papers discussed above. Multivariate sensitivity analyses based on Latin Hypercube Sampling are performed to investigate the effects of input parameters on the control policy structure and the mean cumulative deaths. Additional studies investigate the effects of departures from the modeling assumptions, which include exponential terminal time and linear NPI implementation cost.
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