Selected article for: "elevated baseline and lymphocyte count"
Author: Buonaguro, Franco Maria; Puzanov, Igor; Ascierto, Paolo Antonio
Title: Anti-IL6R role in treatment of COVID-19-related ARDS
  • Document date: 2020_4_14
    • ID: 0pigqtzt_8
    Snippet: Limited experience in Italian centers obtained using tocilizumab for patients with moderate to severe COVID-19 revealed anecdotal evidence of time-correlated clinical improvements in oxygenation, decreased CRP, increased lymphocyte counts 24-48 h post administration, similar to the Chinese experience. Better outcomes were observed in non-intubated patients with elevated baseline level of IL-6 CRP, ferritin and LDH. arm study with primary endpoint.....
    Document: Limited experience in Italian centers obtained using tocilizumab for patients with moderate to severe COVID-19 revealed anecdotal evidence of time-correlated clinical improvements in oxygenation, decreased CRP, increased lymphocyte counts 24-48 h post administration, similar to the Chinese experience. Better outcomes were observed in non-intubated patients with elevated baseline level of IL-6 CRP, ferritin and LDH. arm study with primary endpoint of overall mortality 1 month after registration. Secondary endpoints include predictive/prognostic markers of baseline and on treatment level of IL-6 and CRP, lymphocyte count changes, radiological response, and other cytokine changes. Study will include patients with SARS-CoV-2-induced interstitial pneumonia, respiratory insufficiency (O2sat ≤ 93% or PaO2/FiO2 ratio ≤ 300). Patients should be intubated less than 24 h before registration. In parallel, observational cohort with less stringent enrollment criteria will proceed as well.

    Search related documents:
    Co phrase search for related documents
    • anecdotal evidence and LDH ferritin: 1
    • anecdotal evidence and LDH ferritin crp: 1
    • arm study and baseline level: 1
    • arm study and clinical improvement: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
    • arm study and count change: 1
    • arm study and CRP decrease: 1
    • arm study and interstitial pneumonia: 1, 2, 3, 4, 5
    • arm study and LDH ferritin: 1, 2, 3, 4
    • arm study and LDH ferritin crp: 1, 2
    • baseline level and clinical improvement: 1, 2, 3
    • baseline level and CRP decrease: 1
    • baseline level and LDH ferritin: 1, 2, 3
    • baseline level and LDH ferritin crp: 1, 2, 3
    • baseline level and LDH ferritin crp baseline level: 1
    • clinical improvement and count change: 1
    • clinical improvement and CRP decrease: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • clinical improvement and interstitial pneumonia: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • clinical improvement and LDH ferritin: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
    • clinical improvement and LDH ferritin crp: 1, 2, 3, 4, 5, 6, 7