Author: Hashem, Anwar M.; Flaman, Anathea S.; Farnsworth, Aaron; Brown, Earl G.; Van Domselaar, Gary; He, Runtao; Li, Xuguang
Title: Aurintricarboxylic Acid Is a Potent Inhibitor of Influenza A and B Virus Neuraminidases Document date: 2009_12_17
ID: 13bvkj2t_3
Snippet: Presently, only two classes of antiviral agents have been developed and approved for prophylaxis and treatment of seasonal influenza infection [5, 14] . The first class blocks the influenza M2 protein, which forms hydrogen ion channels required for the efficient uncoating of incoming viruses [5, 14] . The second class inhibits influenza NA, which is required for efficient release of viral particles from the infected cell [5, 14] . However, resist.....
Document: Presently, only two classes of antiviral agents have been developed and approved for prophylaxis and treatment of seasonal influenza infection [5, 14] . The first class blocks the influenza M2 protein, which forms hydrogen ion channels required for the efficient uncoating of incoming viruses [5, 14] . The second class inhibits influenza NA, which is required for efficient release of viral particles from the infected cell [5, 14] . However, resistance to both M2 blockers and NA inhibitors has been reported to be extensive [5, [14] [15] [16] .
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