Author: Oude Munnink, Bas B.; Jazaeri Farsani, Seyed Mohammad; Deijs, Martin; Jonkers, Jiri; Verhoeven, Joost T. P.; Ieven, Margareta; Goossens, Herman; de Jong, Menno D.; Berkhout, Ben; Loens, Katherine; Kellam, Paul; Bakker, Margreet; Canuti, Marta; Cotten, Matthew; van der Hoek, Lia
Title: Autologous Antibody Capture to Enrich Immunogenic Viruses for Viral Discovery Document date: 2013_11_4
ID: 0mu4tkui_5
Snippet: To facilitate the detection of immunogenic viruses and to reduce the detection of non disease-related viruses (bacteriophages and plant viruses) and host cellular RNA, a technique was developed that uses convalescent serum of the patient to concentrate viruses that have elicited and immune response prior to sequencing. Comparing the sequences derived from input and antibody captured material identifies immunogenic agents and can provide an import.....
Document: To facilitate the detection of immunogenic viruses and to reduce the detection of non disease-related viruses (bacteriophages and plant viruses) and host cellular RNA, a technique was developed that uses convalescent serum of the patient to concentrate viruses that have elicited and immune response prior to sequencing. Comparing the sequences derived from input and antibody captured material identifies immunogenic agents and can provide an important first step in identifying a disease-related virus.
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