Author: Hashem, Anwar M.; Flaman, Anathea S.; Farnsworth, Aaron; Brown, Earl G.; Van Domselaar, Gary; He, Runtao; Li, Xuguang
Title: Aurintricarboxylic Acid Is a Potent Inhibitor of Influenza A and B Virus Neuraminidases Document date: 2009_12_17
ID: 13bvkj2t_41
Snippet: During the preparation of this manuscript, we noted that Hung et al. [45] also reported that ATA protects cells from a variety of virus strains in vitro and can inhibit NA in cell-free assays. In our studies, the IC 50 and selective index are higher than those reported by Hung et al. [45] , but we suspect that such discrepancies might be due to differences in experimental conditions. While our two groups have demonstrated that viral NA activity i.....
Document: During the preparation of this manuscript, we noted that Hung et al. [45] also reported that ATA protects cells from a variety of virus strains in vitro and can inhibit NA in cell-free assays. In our studies, the IC 50 and selective index are higher than those reported by Hung et al. [45] , but we suspect that such discrepancies might be due to differences in experimental conditions. While our two groups have demonstrated that viral NA activity is compromised by ATA, it is possible that ATA also targets other viral or cellular proteins to exert its antiinfluenza activity. Additional studies are required to answer this question.
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