Selected article for: "gene expression and mrna expression"
Author: Wang, Kai; Ran, Ling; Yan, Tao; Niu, Zheng; Kan, Zifei; Zhang, Yiling; Yang, Yang; Xie, Luyi; Huang, Shilei; Yu, Qiuhan; Wu, Di; Song, Zhenhui
Title: Anti-TGEV Miller Strain Infection Effect of Lactobacillus plantarum Supernatant Based on the JAK-STAT1 Signaling Pathway
  • Document date: 2019_11_6
    • ID: 05tf6oqa_43
    Snippet: We found that the mRNA expression levels of ZAP, MX2, MX1, PKR, OASL, and ISG15 were significantly higher in the Lp-1s treated group than in the TGEV infected group at various points after infection. The expression levels of ZAP, PKR, OASL, and ISG15 in each experimental group increased with time. The expression levels of MX1 and MX2 peaked at 24 h and then decreased at 48 h (Figures 7A-F) . The results showed that the best time to STAT1-siRNA ta.....
    Document: We found that the mRNA expression levels of ZAP, MX2, MX1, PKR, OASL, and ISG15 were significantly higher in the Lp-1s treated group than in the TGEV infected group at various points after infection. The expression levels of ZAP, PKR, OASL, and ISG15 in each experimental group increased with time. The expression levels of MX1 and MX2 peaked at 24 h and then decreased at 48 h (Figures 7A-F) . The results showed that the best time to STAT1-siRNA targeting gene silencing STAT1 was 48 h (Figure 7G) , and the best interference fragment was STAT1-siRNA1 ( Figure 7H) . After gene silencing STAT1, we found that the expression of ISGs decreased compared to the groups which no knock down STAT1, and the expression ISGs of Lp-1s-treated TGEV infected group was higher than that of TGEV infected alone group (Figures 7I-N) . The results showed that TGEV infection of IPEC-J2 cells treated with Lp-1s could stimulate the expression of ISGs in cells to inhibit viral replication.

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