Author: Oude Munnink, Bas B.; Jazaeri Farsani, Seyed Mohammad; Deijs, Martin; Jonkers, Jiri; Verhoeven, Joost T. P.; Ieven, Margareta; Goossens, Herman; de Jong, Menno D.; Berkhout, Ben; Loens, Katherine; Kellam, Paul; Bakker, Margreet; Canuti, Marta; Cotten, Matthew; van der Hoek, Lia
Title: Autologous Antibody Capture to Enrich Immunogenic Viruses for Viral Discovery Document date: 2013_11_4
ID: 0mu4tkui_35
Snippet: Antibody response to a virus infection can vary, depending on the virus, but also age and immune state of patients. Also, antibodies subclasses can differ; some viruses elicit a strong IgG response, while others induce a response dominated by IgA. In our antibody capture experiment, a combination of protein A and G coupled beads was used. Both proteins strongly bind to IgGs, but not or less efficient to IgA. It has been shown that serum antibodie.....
Document: Antibody response to a virus infection can vary, depending on the virus, but also age and immune state of patients. Also, antibodies subclasses can differ; some viruses elicit a strong IgG response, while others induce a response dominated by IgA. In our antibody capture experiment, a combination of protein A and G coupled beads was used. Both proteins strongly bind to IgGs, but not or less efficient to IgA. It has been shown that serum antibodies, for instance against PIV-1 are not neutralizing efficiently, and that especially secretory IgA plays an important role in preventing re-infection [26, 27] . To address that point, protein L coupled beads, which are able to capture IgA, were tested. However, no difference was observed in the amount of PIV-1 or enterovirus capture (data not shown).
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