Author: Metzger, Vincent T.; Lloyd-Smith, James O.; Weinberger, Leor S.
Title: Autonomous Targeting of Infectious Superspreaders Using Engineered Transmissible Therapies Document date: 2011_3_17
ID: 0gt21051_6
Snippet: By sharing all packaging elements with the wild-type pathogen, TIPs also have the potential to spread between individuals [20] , and would spread via the same transmission routes as the diseasecausing pathogen. In this respect, combating an infectious disease using TIPs raises unique safety and ethical concerns but bears similarity to the use of live attenuated vaccines. In particular, a recognized advantage of Oral Polio Vaccine (OPV) is that it.....
Document: By sharing all packaging elements with the wild-type pathogen, TIPs also have the potential to spread between individuals [20] , and would spread via the same transmission routes as the diseasecausing pathogen. In this respect, combating an infectious disease using TIPs raises unique safety and ethical concerns but bears similarity to the use of live attenuated vaccines. In particular, a recognized advantage of Oral Polio Vaccine (OPV) is that it replicates in vivo and sheds, thereby transmitting among susceptible hosts and delivering additional protection via 'transmissible immunization' at the population scale [21] . There are, however, crucial differences between TIPs and live attenuated vaccines: (i) TIPs cannot replicate in uninfected hosts and, at most, the TIP will remain dormant until the host is coinfected by wildtype pathogen [22] ; and (ii) replication elements are missing from the TIP, so, unlike OPV, TIP cannot revert to virulence in healthy individuals.
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