Selected article for: "activation response and IFN response"
Author: Yu, Liping; Zhang, Xiaorong; Wu, Tianqi; Su, Jin; Wang, Yuyang; Wang, Yuexin; Ruan, Baoyang; Niu, Xiaosai; Wu, Yantao
Title: Avian infectious bronchitis virus disrupts the melanoma differentiation associated gene 5 (MDA5) signaling pathway by cleavage of the adaptor protein MAVS
  • Document date: 2017_11_13
    • ID: 0zn1sqj9_40
    Snippet: Taken together, our study represents a comprehensive analysis of the host antiviral immune response against IBV infection. We show that IBV induces activation of the IFN response in CEK cells and chicken embryos. We also found that chMAVS acts as a key modulator in antiviral signaling by positively regulating chMDA5mediated signaling. dgRIG-I and chMDA5 have similar roles in the IBV-induced IFN-β signaling pathway, the absence of RIG-I may incre.....
    Document: Taken together, our study represents a comprehensive analysis of the host antiviral immune response against IBV infection. We show that IBV induces activation of the IFN response in CEK cells and chicken embryos. We also found that chMAVS acts as a key modulator in antiviral signaling by positively regulating chMDA5mediated signaling. dgRIG-I and chMDA5 have similar roles in the IBV-induced IFN-β signaling pathway, the absence of RIG-I may increase the susceptibility of chickens to IBV infection. The exact contributions of these PRRs and MAVS are worth exploring in future studies.

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