Author: Perdomo, German; Dong, H. Henry
Title: Apolipoprotein D in Lipid Metabolism and Its Functional Implication in Atherosclerosis and Aging Document date: 2008_12_12
ID: 167z915s_30
Snippet: Although apoD is shown to confer a significant beneficial effect on aging in fruit flies, there is a lack of evidence that apoD contributes to lifespan expansion in mammals. It is noteworthy that apoD is abundantly expressed in the brain. Elderly subjects and patients with Alzheimer are associated with markedly elevated apoD production in the brain [72] [73] [74] , but the underlying pathophysiology is unknown. It is important to understand wheth.....
Document: Although apoD is shown to confer a significant beneficial effect on aging in fruit flies, there is a lack of evidence that apoD contributes to lifespan expansion in mammals. It is noteworthy that apoD is abundantly expressed in the brain. Elderly subjects and patients with Alzheimer are associated with markedly elevated apoD production in the brain [72] [73] [74] , but the underlying pathophysiology is unknown. It is important to understand whether and how apoD affects aging and contributes to lifespan expansion in mammals.
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