Author: Yong, Kylie Su Mei; Ng, Justin Han Jia; Her, Zhisheng; Hey, Ying Ying; Tan, Sue Yee; Tan, Wilson Wei Sheng; Irac, Sergio Erdal; Liu, Min; Chan, Xue Ying; Gunawan, Merry; Foo, Randy Jee Hiang; Low, Dolyce Hong Wen; Mendenhall, Ian Hewitt; Chionh, Yok Teng; Dutertre, Charles-Antoine; Chen, Qingfeng; Wang, Lin-Fa
Title: Bat-mouse bone marrow chimera: a novel animal model for dissecting the uniqueness of the bat immune system Document date: 2018_3_16
ID: 01f36rld_3
Snippet: Graft rejection is a severe disorder that has gained significant importance because of the increasing application of cell and tissue transplants 32 . It has been reported that the engraftment of immunologically incompatible mature cells into species such as rodent, avian, primate and human are capable of triggering graft rejection responses [32] [33] [34] [35] [36] . Graft rejection is the most frequent complication after transplantation and is a.....
Document: Graft rejection is a severe disorder that has gained significant importance because of the increasing application of cell and tissue transplants 32 . It has been reported that the engraftment of immunologically incompatible mature cells into species such as rodent, avian, primate and human are capable of triggering graft rejection responses [32] [33] [34] [35] [36] . Graft rejection is the most frequent complication after transplantation and is a consequence of interactions between antigen-presenting cells of the recipients and mature T cells of the donor 37, 38 . In clinics, mature T cells have to be depleted from donor tissues or only purified stem/progenitor cells can be used for transplantation in order to reduce the risk of rejection 39, 40 . Because of this, the success of clinical transplantation is largely limited by the immunological incompatibility between donor and host cell/tissue and the high cost of tissue processing 32 . Additionally, in order to achieve successful and stable long-term reconstitution of human immune cells in humanized mice, purified stem cells completely devoid of mature T cells are required to prevent the development of graft rejection 41 .
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