Author: Gwon, Yong-Dae; Strand, Mårten; Lindqvist, Richard; Nilsson, Emma; Saleeb, Michael; Elofsson, Mikael; Överby, Anna K.; Evander, Magnus
Title: Antiviral Activity of Benzavir-2 against Emerging Flaviviruses Document date: 2020_3_22
ID: 0ym40eki_54
Snippet: Ribavirin is a well-known nucleotide analog and its anti-flavivirus activity has previously been reported [20, 35] . Ribavirin showed moderate anti-ZIKV activity in our assay (EC 50 value of 45.5 ± 13.5 µM and EC 90 value of 114.5 ± 18.0 µM), consistent with previous reports displaying a variable efficacy range of ribavirin against ZIKV (EC 50 between 20 and 48 µM) [37] [38] [39] . Favipiravir failed to display anti-ZIKV activity in our assa.....
Document: Ribavirin is a well-known nucleotide analog and its anti-flavivirus activity has previously been reported [20, 35] . Ribavirin showed moderate anti-ZIKV activity in our assay (EC 50 value of 45.5 ± 13.5 µM and EC 90 value of 114.5 ± 18.0 µM), consistent with previous reports displaying a variable efficacy range of ribavirin against ZIKV (EC 50 between 20 and 48 µM) [37] [38] [39] . Favipiravir failed to display anti-ZIKV activity in our assay. Lei Cai et al. have showed an EC 50 value above 100 µM (EC 50 was 110.9 ± 13.1 µM) for favipiravir, which was the highest compound concentration in our assay [40] . Thus, antiviral activity might have been observed with increased concentration of favipiravir.
Search related documents:
Co phrase search for related documents- antiviral activity and efficacy range: 1, 2, 3, 4
- antiviral activity and increase concentration: 1, 2, 3
- antiviral activity and nucleotide analog: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- antiviral activity and previous report: 1, 2, 3, 4, 5, 6
- assay compound concentration and compound concentration: 1
- compound concentration and previous report: 1, 2
- increase concentration and previous report: 1
Co phrase search for related documents, hyperlinks ordered by date