Author: Gwon, Yong-Dae; Strand, Mårten; Lindqvist, Richard; Nilsson, Emma; Saleeb, Michael; Elofsson, Mikael; Överby, Anna K.; Evander, Magnus
Title: Antiviral Activity of Benzavir-2 against Emerging Flaviviruses Document date: 2020_3_22
ID: 0ym40eki_60
Snippet: The lack of available antiviral drugs to treat flaviviruses made us assess the antiviral activity of benzavir-2 on additional medically-important members of the flavivirus genus. The antiviral effect of benzavir-2 and ribavirin was assessed by focus forming assay on six different wild-type flaviviruses (BSL3 classified: TBEV, WNV, JEV, YFV, DENV2, and BSL2+ classified: ZIKV as a reference). Strikingly, benzavir-2 at 2.5 µM displayed potent antiv.....
Document: The lack of available antiviral drugs to treat flaviviruses made us assess the antiviral activity of benzavir-2 on additional medically-important members of the flavivirus genus. The antiviral effect of benzavir-2 and ribavirin was assessed by focus forming assay on six different wild-type flaviviruses (BSL3 classified: TBEV, WNV, JEV, YFV, DENV2, and BSL2+ classified: ZIKV as a reference). Strikingly, benzavir-2 at 2.5 µM displayed potent antiviral activity, reducing viral titers with three to five orders of magnitude against all tested flaviviruses.
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