Author: Labrie, Marilyne; Lalonde, Simon; Najyb, Ouafa; Thiery, Maxime; Daneault, Caroline; Des Rosiers, Chrisitne; Rassart, Eric; Mounier, Catherine
Title: Apolipoprotein D Transgenic Mice Develop Hepatic Steatosis through Activation of PPAR? and Fatty Acid Uptake Document date: 2015_6_17
ID: 0wtq1c15_28
Snippet: Using the H-apoD Tg mice, we previously demonstrated that hepatic PPARγ mRNA was increased [15] . In the present study, we showed that both PPARγ1 and γ2 mRNA levels are increased (1.37-fold and 1.16-fold Tg vs WT respectively) (Fig 1A) . At the protein level, PPARγ1 was increased by 2.24-fold in Tg mice while PPARγ2 was poorly detected (Fig 1B) . The expression of C/EBPα mRNA, an early marker of adipogenic-like phenotype and a PPARγ targe.....
Document: Using the H-apoD Tg mice, we previously demonstrated that hepatic PPARγ mRNA was increased [15] . In the present study, we showed that both PPARγ1 and γ2 mRNA levels are increased (1.37-fold and 1.16-fold Tg vs WT respectively) (Fig 1A) . At the protein level, PPARγ1 was increased by 2.24-fold in Tg mice while PPARγ2 was poorly detected (Fig 1B) . The expression of C/EBPα mRNA, an early marker of adipogenic-like phenotype and a PPARγ target gene was also increased (Fig 1C) while C/EBPβ, which is not a PPARγ target, remained unchanged ( Fig 1D) .
Search related documents:
Co phrase search for related documents- early marker and present study: 1, 2, 3, 4, 5, 6
- level Tg increase and Tg increase: 1
- pparγ target and present study: 1
- pparγ target and target gene: 1, 2
- pparγ target and Tg increase: 1
- PPARγ target gene and target gene: 1, 2
- PPARγ1 increase and Tg increase: 1
- present study and protein level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- present study and target gene: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- present study and Tg increase: 1, 2
- protein level and target gene: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- protein level and Tg increase: 1
Co phrase search for related documents, hyperlinks ordered by date