Selected article for: "mRNA expression and protein level"
Author: Labrie, Marilyne; Lalonde, Simon; Najyb, Ouafa; Thiery, Maxime; Daneault, Caroline; Des Rosiers, Chrisitne; Rassart, Eric; Mounier, Catherine
Title: Apolipoprotein D Transgenic Mice Develop Hepatic Steatosis through Activation of PPAR? and Fatty Acid Uptake
  • Document date: 2015_6_17
    • ID: 0wtq1c15_28
    Snippet: Using the H-apoD Tg mice, we previously demonstrated that hepatic PPARγ mRNA was increased [15] . In the present study, we showed that both PPARγ1 and γ2 mRNA levels are increased (1.37-fold and 1.16-fold Tg vs WT respectively) (Fig 1A) . At the protein level, PPARγ1 was increased by 2.24-fold in Tg mice while PPARγ2 was poorly detected (Fig 1B) . The expression of C/EBPα mRNA, an early marker of adipogenic-like phenotype and a PPARγ targe.....
    Document: Using the H-apoD Tg mice, we previously demonstrated that hepatic PPARγ mRNA was increased [15] . In the present study, we showed that both PPARγ1 and γ2 mRNA levels are increased (1.37-fold and 1.16-fold Tg vs WT respectively) (Fig 1A) . At the protein level, PPARγ1 was increased by 2.24-fold in Tg mice while PPARγ2 was poorly detected (Fig 1B) . The expression of C/EBPα mRNA, an early marker of adipogenic-like phenotype and a PPARγ target gene was also increased (Fig 1C) while C/EBPβ, which is not a PPARγ target, remained unchanged ( Fig 1D) .

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