Author: Labrie, Marilyne; Lalonde, Simon; Najyb, Ouafa; Thiery, Maxime; Daneault, Caroline; Des Rosiers, Chrisitne; Rassart, Eric; Mounier, Catherine
Title: Apolipoprotein D Transgenic Mice Develop Hepatic Steatosis through Activation of PPAR? and Fatty Acid Uptake Document date: 2015_6_17
ID: 0wtq1c15_47
Snippet: Challenging our observations, Perdomo et al. [58] showed that, in mice injected with an adenovirus expressing apoD, the activation of LPL leads to a decrease in circulating TG-rich lipoproteins. The authors did not observe any accumulation of ectopic fat in the liver. The difference between their study and this one could be attributed to the fact that the adenovirus half-life in mice is certainly too short to allow development of steatosis. Also,.....
Document: Challenging our observations, Perdomo et al. [58] showed that, in mice injected with an adenovirus expressing apoD, the activation of LPL leads to a decrease in circulating TG-rich lipoproteins. The authors did not observe any accumulation of ectopic fat in the liver. The difference between their study and this one could be attributed to the fact that the adenovirus half-life in mice is certainly too short to allow development of steatosis. Also, the use of adenoviruses to overexpress apoD may lead to a different level of apoD expression in the liver.
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