Author: Carabineiro, Sónia Alexandra Correia
Title: Applications of Gold Nanoparticles in Nanomedicine: Recent Advances in Vaccines † Document date: 2017_5_22
ID: 0nz0qioh_62
Snippet: Synthetic virus-like particles (sVLPs) were prepared by incubating 100 nm gold nanoparticles in a solution containing an avian coronavirus spike protein [127] . After removing the free proteins, antigen-laden particles were recovered and showed morphological semblance to natural viral particles. Vaccination with the sVLPs showed enhanced lymphatic antigen delivery, stronger antibody titers, increased splenic T-cell response, and reduced infection.....
Document: Synthetic virus-like particles (sVLPs) were prepared by incubating 100 nm gold nanoparticles in a solution containing an avian coronavirus spike protein [127] . After removing the free proteins, antigen-laden particles were recovered and showed morphological semblance to natural viral particles. Vaccination with the sVLPs showed enhanced lymphatic antigen delivery, stronger antibody titers, increased splenic T-cell response, and reduced infection-associated symptoms, and provided superior antiviral protection when compared to a commercial whole inactivated virus vaccine [127] .
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