Selected article for: "control cell and protein expression"
Author: Miguel, Maria Graça
Title: Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
  • Document date: 2010_12_15
    • ID: 1dfzj1b3_118
    Snippet: The anti-inflammatory activities of PPARs are partially effectuated by inhibition of NF-κB. PPARs are able to attenuate NF-κB function either by interfering with the transcription activating capacity of the NF-κB complex or by regulating genes that suppress the activation of NF-κB. By physical interaction with components of the NF-κB complex, PPARα impairs binding of NF-κB to the DNA and subsequent activation of inflammatory genes. Secondl.....
    Document: The anti-inflammatory activities of PPARs are partially effectuated by inhibition of NF-κB. PPARs are able to attenuate NF-κB function either by interfering with the transcription activating capacity of the NF-κB complex or by regulating genes that suppress the activation of NF-κB. By physical interaction with components of the NF-κB complex, PPARα impairs binding of NF-κB to the DNA and subsequent activation of inflammatory genes. Secondly, PPARα activation results in increased expression of IκB, the inhibitory protein that prevents the transfer of NF-κB to the nucleus [134, 135] . On the other hand, Inoue et al. (2000) [136] consider that COX-2 expression is regulated by a negative feedback loop, mediated through PPARγ, especially in macrophages, indicating that PPARγ participates in cell type-specific control of COX-2 expression.

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