Author: Jiang, Yuting; Zhao, Guangyu; Song, Nianping; Li, Pei; Chen, Yuehong; Guo, Yan; Li, Junfeng; Du, Lanying; Jiang, Shibo; Guo, Renfeng; Sun, Shihui; Zhou, Yusen
Title: Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV Document date: 2018_4_24
ID: 0kihygau_28
Snippet: To determine if complement activation influences viral replication, the viral titer in lung tissues, as well as antigen expression, was assessed. Compared to the PBS treatment group, the results showed that lung tissue exhibited less viral antigen expression (Fig. 3a, b) with lower viral titers and viral replication (Fig. 3c, d) in the anti-C5aR Ab treatment group. These results indicated that inhibition of complement activation could limit MERS-.....
Document: To determine if complement activation influences viral replication, the viral titer in lung tissues, as well as antigen expression, was assessed. Compared to the PBS treatment group, the results showed that lung tissue exhibited less viral antigen expression (Fig. 3a, b) with lower viral titers and viral replication (Fig. 3c, d) in the anti-C5aR Ab treatment group. These results indicated that inhibition of complement activation could limit MERS-CoV replication in the lung.
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