Author: Jiang, Yuting; Zhao, Guangyu; Song, Nianping; Li, Pei; Chen, Yuehong; Guo, Yan; Li, Junfeng; Du, Lanying; Jiang, Shibo; Guo, Renfeng; Sun, Shihui; Zhou, Yusen
Title: Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV Document date: 2018_4_24
ID: 0kihygau_34
Snippet: We next evaluated the effect of the anti-C5aR Ab treatment on viral titers and inflammation in the brain, including the olfactory bulb, cerebral cortex, and hippocampus, on day 7 post-infection. The results showed that there was less viral antigen and less activated microglia in the brains of the anti-C5aR Ab-treated mice compared with the untreated mice (data not shown). This result suggests that the anti-C5aR treatment could also suppress the i.....
Document: We next evaluated the effect of the anti-C5aR Ab treatment on viral titers and inflammation in the brain, including the olfactory bulb, cerebral cortex, and hippocampus, on day 7 post-infection. The results showed that there was less viral antigen and less activated microglia in the brains of the anti-C5aR Ab-treated mice compared with the untreated mice (data not shown). This result suggests that the anti-C5aR treatment could also suppress the inflammatory response and alleviate damage to brain tissues caused by MERS-CoV infection.
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