Selected article for: "cell regeneration and MERS cov"
Author: Jiang, Yuting; Zhao, Guangyu; Song, Nianping; Li, Pei; Chen, Yuehong; Guo, Yan; Li, Junfeng; Du, Lanying; Jiang, Shibo; Guo, Renfeng; Sun, Shihui; Zhou, Yusen
Title: Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV
  • Document date: 2018_4_24
    • ID: 0kihygau_4
    Snippet: High pathogenicity accompanied by increasingly severe dysregulation of immune responses in MERS-CoVinfected patients prompted us to explore the potential role of complement in the pathogenesis of MERS-CoV. Therefore, in this study, we demonstrate that MERS-CoV infection induced complement overactivation and led to severe lung damage, but that blockade of the interaction between C5a and C5aR alleviated tissue injury by reestablishing normal local .....
    Document: High pathogenicity accompanied by increasingly severe dysregulation of immune responses in MERS-CoVinfected patients prompted us to explore the potential role of complement in the pathogenesis of MERS-CoV. Therefore, in this study, we demonstrate that MERS-CoV infection induced complement overactivation and led to severe lung damage, but that blockade of the interaction between C5a and C5aR alleviated tissue injury by reestablishing normal local and systemic immune responses, including reduced infiltration of tissue macrophages, inflammatory cytokine expression, and apoptosis of splenic cells and increased T cell regeneration. Therefore, it is suggested that complement inhibition may be a promising interventional strategy for treating MERS-CoV-infected patients.

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