Selected article for: "blood borne and disease transmission"
Author: Metzger, Vincent T.; Lloyd-Smith, James O.; Weinberger, Leor S.
Title: Autonomous Targeting of Infectious Superspreaders Using Engineered Transmissible Therapies
  • Document date: 2011_3_17
    • ID: 0gt21051_1
    Snippet: From 'core groups' to 'superspreaders', epidemiologists have long recognized the immense potential of targeting high-risk groups for efficient control of infectious diseases [1, 2, 3, 4] . These groups are often described by the classic '80/20 rule' [5] where 20% of the individuals drive 80% of disease transmission and thus dominate the overall pattern of disease prevalence. For sexually transmitted and blood-borne infections such as Hepatitis C .....
    Document: From 'core groups' to 'superspreaders', epidemiologists have long recognized the immense potential of targeting high-risk groups for efficient control of infectious diseases [1, 2, 3, 4] . These groups are often described by the classic '80/20 rule' [5] where 20% of the individuals drive 80% of disease transmission and thus dominate the overall pattern of disease prevalence. For sexually transmitted and blood-borne infections such as Hepatitis C [6] , syphilis [7] , and HIV-1 [8, 9] (here termed HIV), superspreading is driven by high-risk sexual or needle-sharing behaviors. For many other pathogens, spanning a broad range of transmission modes and life histories, superspreading plays an important role in transmission dynamics but the underlying mechanisms remain poorly understood [4, 10, 11] .

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