Selected article for: "pathway inhibit and signaling pathway"
Author: Hermesh, Tamar; Moltedo, Bruno; López, Carolina B.; Moran, Thomas M.
Title: Buying Time—The Immune System Determinants of the Incubation Period to Respiratory Viruses
  • Document date: 2010_11_18
    • ID: 0yqv2osb_34
    Snippet: Respiratory paramyxoviruses can inhibit the IFN signaling pathway. The C protein of hPIV1 inhibits the translocation of STAT-1 and STAT-2 to the nucleus and the activation of IRF-3 [82, 83] , while the C protein of hPIV3 inhibits the phosphorylation of STAT-1 [84] . Some evidence suggests the C protein of MeV acts to inhibit IFN signaling response [85] . The V protein of MeV appears to form complexes with different signaling proteins in the IFN r.....
    Document: Respiratory paramyxoviruses can inhibit the IFN signaling pathway. The C protein of hPIV1 inhibits the translocation of STAT-1 and STAT-2 to the nucleus and the activation of IRF-3 [82, 83] , while the C protein of hPIV3 inhibits the phosphorylation of STAT-1 [84] . Some evidence suggests the C protein of MeV acts to inhibit IFN signaling response [85] . The V protein of MeV appears to form complexes with different signaling proteins in the IFN response pathway preventing either nuclear translocation or their phosphorylation [86] [87] [88] [89] [90] [91] . The NS1 and NS2 proteins of RSV can both block type I IFN and IFN-λ responses [92, 93] . It is thought that STAT2 is actually degraded by NS1 and NS2 [94] (Figure 1) .

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