Author: Hermesh, Tamar; Moltedo, Bruno; López, Carolina B.; Moran, Thomas M.
Title: Buying Time—The Immune System Determinants of the Incubation Period to Respiratory Viruses Document date: 2010_11_18
ID: 0yqv2osb_45
Snippet: Intracellular purine metabolites are released from damaged cells and include uric acid and ATP, which can stimulate the inflammasome complex to cleave pro-IL-1β and intensify the innate response [47, [103] [104] [105] [106] [107] [108] [109] . The inflammasome can also activate type I IFNs production [45] and type I IFNs itself can upregulate AIM2, a protein that contains a pyrin motif that is necessary for promoting IL-1β production. IFN-γ is.....
Document: Intracellular purine metabolites are released from damaged cells and include uric acid and ATP, which can stimulate the inflammasome complex to cleave pro-IL-1β and intensify the innate response [47, [103] [104] [105] [106] [107] [108] [109] . The inflammasome can also activate type I IFNs production [45] and type I IFNs itself can upregulate AIM2, a protein that contains a pyrin motif that is necessary for promoting IL-1β production. IFN-γ is also involved in this signaling cascade since it can upregulate components of the inflammasome complex [110, 111] .
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