Author: Hermesh, Tamar; Moltedo, Bruno; López, Carolina B.; Moran, Thomas M.
Title: Buying Time—The Immune System Determinants of the Incubation Period to Respiratory Viruses Document date: 2010_11_18
ID: 0yqv2osb_20
Snippet: The first indication of an immune response to virus infection is the secretion of type I IFNs. Type I IFNs belong to a family of cytokines consisting of one subtype of IFN-β, 13 subtypes of IFN-α and also IFN-ω, IFN-κ, IFN-ε and IFN-ν. Type III IFNs (IFN-λ) are also produced quickly after infection, and although their function and regulation is less studied than that of type I IFNs, they share similar functions. The existence of multiple I.....
Document: The first indication of an immune response to virus infection is the secretion of type I IFNs. Type I IFNs belong to a family of cytokines consisting of one subtype of IFN-β, 13 subtypes of IFN-α and also IFN-ω, IFN-κ, IFN-ε and IFN-ν. Type III IFNs (IFN-λ) are also produced quickly after infection, and although their function and regulation is less studied than that of type I IFNs, they share similar functions. The existence of multiple IFN-α genes and the fact that virtually all viruses encode proteins that antagonize the production or response to type I IFNs emphasizes their importance during the anti-viral immune response. As we will discuss in more detail later in this review, type I IFNs secretion is delayed in vivo until a few days after infection and is coincident with the end of the incubation period.
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