Author: Chen, Shilong; Wang, Long; Chen, Jieying; Zhang, Lanlan; Wang, Song; Goraya, Mohsan U.; Chi, Xiaojuan; Na, Yang; Shao, Wenhan; Yang, Zhou; Zeng, Xiancheng; Chen, Shaoying; Chen, Ji-Long
Title: Avian Interferon-Inducible Transmembrane Protein Family Effectively Restricts Avian Tembusu Virus Infection Document date: 2017_4_20
ID: 0pjg25kn_46
Snippet: Our previous work demonstrated that pretreatment of cells with IFNs could significantly impair ATMUV replication (Chen et al., 2016a) . Our present study further provides the evidence that host IFITM proteins have the ability to control the ATMUV infection and likely restrict the viral reproduction as well. Taken together, ATMUV infection induces host's effective antiviral immune response involving several critical IFNs and IFITMs proteins, which.....
Document: Our previous work demonstrated that pretreatment of cells with IFNs could significantly impair ATMUV replication (Chen et al., 2016a) . Our present study further provides the evidence that host IFITM proteins have the ability to control the ATMUV infection and likely restrict the viral reproduction as well. Taken together, ATMUV infection induces host's effective antiviral immune response involving several critical IFNs and IFITMs proteins, which can be useful for developing new antiviral drugs in future. However, further studies are required for better understanding of precise mechanisms underlying the antiviral activity of IFITM proteins.
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