Selected article for: "glomerular filtration membrane pass and renal function"
Author: Xu-wei Hong; Ze-pai Chi; Guo-yuan Liu; Hong Huang; Shun-qi Guo; Jing-ru Fan; Xian-wei Lin; Liao-zhun Qu; Rui-lie Chen; Ling-jie Wu; Liang-yu Wang; Qi-chuan Zhang; Su-wu Wu; Ze-qun Pan; Hao Lin; Yu-hua Zhou; Yong-hai Zhang
Title: Analysis of early renal injury in COVID-19 and diagnostic value of multi-index combined detection
  • Document date: 2020_3_10
    • ID: f3indt3b_30
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.07.20032599 doi: medRxiv preprint the single-cell RNA sequencing datasets to explore the expression of ACE2 in the main physiological systems of the human body, including the respiratory, cardiovascular, digestive and urinary system. The study showed that heart, esophagus, kidney, bladder, and ileum have similar or higher ACE2 expression .....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.07.20032599 doi: medRxiv preprint the single-cell RNA sequencing datasets to explore the expression of ACE2 in the main physiological systems of the human body, including the respiratory, cardiovascular, digestive and urinary system. The study showed that heart, esophagus, kidney, bladder, and ileum have similar or higher ACE2 expression than in alveoli. In the analysis of specific cell types, the expression of ACE2 in renal proximal tubule cells was about four times higher than that of type II alveolar cells (AT2). The results suggest that the kidney may be one of the primary targets of attack for the 2019-nCov. α 1-microglobulin can pass through the glomerular filtration membrane, and 95% to 99% is reabsorbed in the proximal tubule, and it is not affected by pH. In the early stage of renal injury, the renal tubule reabsorption function reduced, resulting in urine α 1-microglobulin excretion increased, and the elevation is consistent with the degree of renal tubular injury.

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