Selected article for: "APTT thromboplastin time and thromboplastin time"
Author: Orwoll, Benjamin E.; Sapru, Anil
Title: Biomarkers in Pediatric ARDS: Future Directions
  • Document date: 2016_6_1
    • ID: 0n5apnle_12
    Snippet: In the classic pathological description of ARDS, the alveolar spaces are filled with a proteinaceous complex that forms the characteristic hyaline membranes (7). This complex is composed of, in large part, fibrin and fibrin breakdown products in addition to pulmonary edema fluid and inflammatory infiltrates. This suggests a role for disordered coagulation homeostasis in ARDS and related conditions, and preclinical models support the role of pulmo.....
    Document: In the classic pathological description of ARDS, the alveolar spaces are filled with a proteinaceous complex that forms the characteristic hyaline membranes (7). This complex is composed of, in large part, fibrin and fibrin breakdown products in addition to pulmonary edema fluid and inflammatory infiltrates. This suggests a role for disordered coagulation homeostasis in ARDS and related conditions, and preclinical models support the role of pulmonary coagulopathy as a pathologic mechanism in ALI (91) . Derangements in typical measures of function of the coagulation system, such as the prothrombin time (PT) and activated thromboplastin time (aPTT), have been associated with increased mortality and organ failure in children with ARDS (92) .

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