Author: Barzon, Luisa; Lavezzo, Enrico; Militello, Valentina; Toppo, Stefano; Palù, Giorgio
Title: Applications of Next-Generation Sequencing Technologies to Diagnostic Virology Document date: 2011_11_14
ID: 01nuj0lk_32
Snippet: High mutation rates inherent to replication of RNA viruses create a wide variety of mutants that are present in virus populations, which are often referred to as quasispecies [80] . The diffuse, "cloud-like" nature of viral populations allows them to rapidly adapt to changing replicative environments by selecting preexisting variants with better fitness [81, 82] . Thus, many important virus properties cannot be explained by a mere consensus seque.....
Document: High mutation rates inherent to replication of RNA viruses create a wide variety of mutants that are present in virus populations, which are often referred to as quasispecies [80] . The diffuse, "cloud-like" nature of viral populations allows them to rapidly adapt to changing replicative environments by selecting preexisting variants with better fitness [81, 82] . Thus, many important virus properties cannot be explained by a mere consensus sequence, but require knowledge about the microvariants present in viral populations. These sequence variants may be critically relevant to viral evolution and spread, virulence, evasion of the immune response, anti-viral drug resistance, and vaccine development and manufacture.
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