Selected article for: "deep sequencing and low frequency"
Author: Barzon, Luisa; Lavezzo, Enrico; Militello, Valentina; Toppo, Stefano; Palù, Giorgio
Title: Applications of Next-Generation Sequencing Technologies to Diagnostic Virology
  • Document date: 2011_11_14
    • ID: 01nuj0lk_43
    Snippet: Several studies that employed 454 pyrosequencing for deep analysis of mutations in HIV protease and reverse transcriptase genes demonstrated the accuracy of this technique in detecting all drug-resistance mutations identified by population sequencing, and the ability to detect low-frequency mutations undetectable by population sequencing [100, 102, 103] . In addition, several studies demonstrated that drug-resistance mutations detected by 454 had.....
    Document: Several studies that employed 454 pyrosequencing for deep analysis of mutations in HIV protease and reverse transcriptase genes demonstrated the accuracy of this technique in detecting all drug-resistance mutations identified by population sequencing, and the ability to detect low-frequency mutations undetectable by population sequencing [100, 102, 103] . In addition, several studies demonstrated that drug-resistance mutations detected by 454 had a significant impact on virological failure [103] [104] [105] [106] [107] while others did not find a strong association of low-frequency mutations with clinical responses [108, 109] . Deep sequencing using the 454 platform has been also applied to investigate drug-resistance mutations against the more recently approved integrase inhibitors and CCR5 antagonists.

    Search related documents:
    Co phrase search for related documents
    • clinical response and deep sequencing: 1
    • clinical response and drug resistance: 1, 2, 3
    • clinical response and HIV protease: 1
    • clinical response and population sequencing: 1
    • clinical response and significant impact: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • clinical response and transcriptase gene: 1
    • clinical response and transcriptase gene reverse: 1
    • deep analysis and drug resistance: 1
    • deep analysis and low frequency: 1, 2
    • deep analysis and population sequence: 1, 2
    • deep analysis and population sequencing: 1
    • deep analysis and strong association: 1, 2
    • deep sequencing and drug resistance: 1, 2, 3, 4, 5, 6, 7, 8
    • deep sequencing and drug resistance mutation: 1
    • deep sequencing and low frequency: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • deep sequencing and population sequencing: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
    • drug resistance and HIV protease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
    • drug resistance and HIV protease mutation: 1, 2, 3
    • drug resistance and integrase inhibitor: 1, 2, 3