Author: Orwoll, Benjamin E.; Sapru, Anil
Title: Biomarkers in Pediatric ARDS: Future Directions Document date: 2016_6_1
ID: 0n5apnle_26
Snippet: Soluble thrombomodulin (sTM) is a circulating protein formed as a result of proteolytic cleavage of cellular thrombomodulin, a membrane bound protein involved in coagulation and inflammatory pathways, and has been identified as a marker of endothelial injury (149, 150) . Our group has found significant relationships between early elevations in plasma sTM and organ failure in a large pARDS cohort, and sTM was predictive of mortality in a subset of.....
Document: Soluble thrombomodulin (sTM) is a circulating protein formed as a result of proteolytic cleavage of cellular thrombomodulin, a membrane bound protein involved in coagulation and inflammatory pathways, and has been identified as a marker of endothelial injury (149, 150) . Our group has found significant relationships between early elevations in plasma sTM and organ failure in a large pARDS cohort, and sTM was predictive of mortality in a subset of those patients with indirect mechanisms of lung injury (45) . These findings were consistent with previous results from our group in adult patients with ARDS (151) and may hint at potential opportunities for endothelial functional replacement through the use of recombinant thrombomodulin, which has been increasingly used in cases of sepsis and critical coagulopathies (152) (153) (154) .
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