Calf-Level Factors Associated with Bovine Neonatal Pancytopenia – A Multi-Country Case-Control Study

Jones, Bryony A.; Sauter-Louis, Carola; Henning, Joerg; Stoll, Alexander; Nielen, Mirjam; Van Schaik, Gerdien; Smolenaars, Anja; Schouten, Matthijs; den Uijl, Ingrid; Fourichon, Christine; Guatteo, Raphael; Madouasse, Aurélien; Nusinovici, Simon; Deprez, Piet; De Vliegher, Sarne; Laureyns, Jozef; Booth, Richard; Cardwell, Jackie M.; Pfeiffer, Dirk U.

There was evidence of interaction between dam PregSurevaccinated and lactation number, between dam PregSure-vaccinated and colostrum from different cow(s), and between lactation number and colostrum from different cow(s). Including two-way interactions between dam PregSure-vaccinated and lactation number and between dam PregSure-vaccinated and colostrum from different cow(s) was a better fit than the models with single interactions or all three interactions. The odds of a case having a second lactation dam were five times the odds of having a first lactation dam, if the dam was PregSurevaccinated (interaction term adjusted matched odds ratio -amOR 4.8; ci 1.1, 20.7; p = 0.034), and the odds of having a vaccinated third or more lactation dam were 7 times the odds of having a vaccinated first lactation dam (interaction term amOR 7.4; ci 1.9, 28.9; p = 0.004). The odds of a case having received colostrum from different cow(s) were 90% lower than the odds of not having received colostrum from other cows, if the dam was PregSurevaccinated (interaction terms amOR 0.1; ci 0.01, 0.95; p = 0.046).