Selected article for: "evolutionary rate and mutation rate"
Author: Metzger, Vincent T.; Lloyd-Smith, James O.; Weinberger, Leor S.
Title: Autonomous Targeting of Infectious Superspreaders Using Engineered Transmissible Therapies
  • Document date: 2011_3_17
    • ID: 0gt21051_23
    Snippet: Vaccines and drug treatment strategies also face the challenge of mutation and the strong selective pressure for the pathogen to escape any successful control. For HIV, rapid mutation leads to resistance against anti-retroviral therapy and poses significant challenges for vaccine development [40] . However, unlike conventional therapies, TIPs replicate with the same speed and mutation rate as the pathogen, which sets up an evolutionary arms race .....
    Document: Vaccines and drug treatment strategies also face the challenge of mutation and the strong selective pressure for the pathogen to escape any successful control. For HIV, rapid mutation leads to resistance against anti-retroviral therapy and poses significant challenges for vaccine development [40] . However, unlike conventional therapies, TIPs replicate with the same speed and mutation rate as the pathogen, which sets up an evolutionary arms race between the TIP and the pathogen.

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