Author: Metzger, Vincent T.; Lloyd-Smith, James O.; Weinberger, Leor S.
Title: Autonomous Targeting of Infectious Superspreaders Using Engineered Transmissible Therapies Document date: 2011_3_17
ID: 0gt21051_28
Snippet: To fully address safety, there is obviously a need for cautious trials in vitro, and in vivo, before a TIP intervention could ever be considered for implementation. Importantly, TIPs for HIV would not specifically target, or require, stem cells since the TIP would target the same cells as HIV (primarily CD4 + T lymphocytes) and thus oncogenic concerns as a result of insertional mutagenesis [47] are minimized. This argument is supported by a recen.....
Document: To fully address safety, there is obviously a need for cautious trials in vitro, and in vivo, before a TIP intervention could ever be considered for implementation. Importantly, TIPs for HIV would not specifically target, or require, stem cells since the TIP would target the same cells as HIV (primarily CD4 + T lymphocytes) and thus oncogenic concerns as a result of insertional mutagenesis [47] are minimized. This argument is supported by a recent Phase-I lentiviral gene-therapy clinical trial for HIV [17] and previous gene therapy in peripheral blood lymphocytes in patients followed since 1995 [48] , neither of which detected insertional mutagenesis or oncogenic transformation in patients.
Search related documents:
Co phrase search for related documents- blood lymphocyte and peripheral blood lymphocyte: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell target and clinical trial: 1, 2, 3
- cell target and gene therapy: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- clinical trial and gene therapy: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- clinical trial and gene therapy HIV clinical trial: 1, 2
- clinical trial and HIV clinical trial: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- clinical trial and peripheral blood lymphocyte: 1, 2, 3, 4
- gene therapy and HIV clinical trial: 1, 2
- gene therapy and insertional mutagenesis: 1, 2, 3
- gene therapy HIV clinical trial and HIV clinical trial: 1, 2
Co phrase search for related documents, hyperlinks ordered by date