Author: McLeod, Robbie L.; Angagaw, Minilik H.; Baral, Toya Nath; Liu, Liming; Moniz, Raymond Joseph; Laskey, Jason; Hsieh, SuChun; Lee, Mike; Han, Jin-Hwan; Issafras, Hassan; Javaid, Sarah; Loboda, Andrey; Sadekova, Svetlana; O'Connor, Joann A.; Tse, Archie; Punnonen, Juha
Title: Characterization of murine CEACAM1 in vivo reveals low expression on CD8(+) T cells and no tumor growth modulating activity by anti-CEACAM1 mAb CC1 Document date: 2018_10_2
ID: 01id7jq6_23
Snippet: We next studied the possibility that the CC1 Ab modulated the phenotypes of tumor infiltrating immune cells. Flow cytometry analysis of tumor-infiltrating cells freshly isolated from syngeneic tumors revealed no changes in the proportions of CD4+, CD8+ T cells, Treg cells, NK cells, B cells, monocytes, dendritic cells or myeloid-derived suppressor cells (myeloid or granulocytic) upon CC1 treatment. In addition, no phenotypic changes were observed.....
Document: We next studied the possibility that the CC1 Ab modulated the phenotypes of tumor infiltrating immune cells. Flow cytometry analysis of tumor-infiltrating cells freshly isolated from syngeneic tumors revealed no changes in the proportions of CD4+, CD8+ T cells, Treg cells, NK cells, B cells, monocytes, dendritic cells or myeloid-derived suppressor cells (myeloid or granulocytic) upon CC1 treatment. In addition, no phenotypic changes were observed in tumor infiltrating T cells derived from mice treated with CC1 as a monotherapy or in combination with the anti-PD-1 Ab.
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