Selected article for: "apoptosis detection and MERS cov"
Author: Jiang, Yuting; Zhao, Guangyu; Song, Nianping; Li, Pei; Chen, Yuehong; Guo, Yan; Li, Junfeng; Du, Lanying; Jiang, Shibo; Guo, Renfeng; Sun, Shihui; Zhou, Yusen
Title: Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV
  • Document date: 2018_4_24
    • ID: 0kihygau_33
    Snippet: Lymphopenia is a primary clinical aspect of severely ill patients 8 . After MERS-CoV infection in our hDPP4transgenic mice, we observed increased apoptosis of splenic cells, as confirmed by the detection of apoptosispositive cells by immunohistochemistry of cleaved caspase-3 and TUNEL methods (Fig. 6a, c) . In comparison, less apoptosis of splenic cells was observed in spleens in the anti-C5aR Ab treatment group (Fig. 6b, d, g) . More interestin.....
    Document: Lymphopenia is a primary clinical aspect of severely ill patients 8 . After MERS-CoV infection in our hDPP4transgenic mice, we observed increased apoptosis of splenic cells, as confirmed by the detection of apoptosispositive cells by immunohistochemistry of cleaved caspase-3 and TUNEL methods (Fig. 6a, c) . In comparison, less apoptosis of splenic cells was observed in spleens in the anti-C5aR Ab treatment group (Fig. 6b, d, g) . More interestingly, increased splenic cell regeneration was clearly evident in the red pulp of mice after the anti-C5aR Ab treatment, which was confirmed by the detection of PCNA expression in spleens by IHC staining (Fig. 6e, f, h) .

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