Author: Hermesh, Tamar; Moltedo, Bruno; López, Carolina B.; Moran, Thomas M.
Title: Buying Time—The Immune System Determinants of the Incubation Period to Respiratory Viruses Document date: 2010_11_18
ID: 0yqv2osb_32
Snippet: TLR agonists are potent inducers of cytokine production. It is, therefore, surprising that very little evidence exists for inhibition of the TLR signaling pathway by the viruses discussed above. It has been suggested that certain RSV strains and MeV can inhibit type I IFN induction by TLR-7 and TLR-9 signaling. In the case of MeV, the V protein acts as a decoy substrate for the kinase IκB kinase α, competing with IRF7 [79] [80] [81] . No eviden.....
Document: TLR agonists are potent inducers of cytokine production. It is, therefore, surprising that very little evidence exists for inhibition of the TLR signaling pathway by the viruses discussed above. It has been suggested that certain RSV strains and MeV can inhibit type I IFN induction by TLR-7 and TLR-9 signaling. In the case of MeV, the V protein acts as a decoy substrate for the kinase IκB kinase α, competing with IRF7 [79] [80] [81] . No evidence exists for such inhibition by Influenza, HRV or human parainfluenza virus (hPIV) (Figure 1 ).
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