Author: Manandhar, Bandana; Paudel, Pradeep; Seong, Su Hui; Jung, Hyun Ah; Choi, Jae Sue
Title: Characterizing Eckol as a Therapeutic Aid: A Systematic Review Document date: 2019_6_18
ID: 0dpv85od_156
Snippet: Human immunodeficiency virus (HIV) is a retrovirus affecting the cells of the human immune system and infecting the vital organs, ultimately causing immune deficiency and leading to acquired immune deficiency syndrome (AIDS). As there is an increase in failure in anti-AIDS treatment due to the strains of the virus becoming drug-resistant, the research for drug candidates with higher rates of inhibition against various strains of HIV is increasing.....
Document: Human immunodeficiency virus (HIV) is a retrovirus affecting the cells of the human immune system and infecting the vital organs, ultimately causing immune deficiency and leading to acquired immune deficiency syndrome (AIDS). As there is an increase in failure in anti-AIDS treatment due to the strains of the virus becoming drug-resistant, the research for drug candidates with higher rates of inhibition against various strains of HIV is increasing with the major focus on naturally derived compounds and their derivatives. The bioassay-directed isolation of E. cava led to the isolation of eckol, 8,8'-bieckol, 8,4 'dieckol, and phlorofucofuroeckol-A. 8,8´-bieckol, 8,4´dieckol inhibited HIV-1 reverse transcriptase (RT), and protease, whereas eckol and phlorofucofuroeckol-A failed to show any activity, even if they were produced from RT inhibitor fractions having ≥80% inhibition (100 mg/mL) [125] .
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