Author: Manandhar, Bandana; Paudel, Pradeep; Seong, Su Hui; Jung, Hyun Ah; Choi, Jae Sue
Title: Characterizing Eckol as a Therapeutic Aid: A Systematic Review Document date: 2019_6_18
ID: 0dpv85od_170
Snippet: According to Sugiura et al. [19] , the suppression of β-hexosaminidase release from RBL-2H3 cells by phlorotannins occurred according to their molecular size or number of phenol groups. Although eckol exhibited significantly lower activity than the positive control, epigallocatechin gallate (IC 50 22 .0 µM), the other isolated phlorotannins 6,8'-bieckol, 6,6'-bieckol, phlorofucofuroeckol-B, and 8,8'-bieckol, phlorofucofuroeckol-A showed inhibit.....
Document: According to Sugiura et al. [19] , the suppression of β-hexosaminidase release from RBL-2H3 cells by phlorotannins occurred according to their molecular size or number of phenol groups. Although eckol exhibited significantly lower activity than the positive control, epigallocatechin gallate (IC 50 22 .0 µM), the other isolated phlorotannins 6,8'-bieckol, 6,6'-bieckol, phlorofucofuroeckol-B, and 8,8'-bieckol, phlorofucofuroeckol-A showed inhibitory activity similar to or greater than epigallocatechin gallate. In model rats fed with a diet including Eisenia arborea, the allergy symptoms improved possibly due to the suppressive effects of the isolated phlorotannins on enzyme and release of histamine.
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