Author: Manandhar, Bandana; Paudel, Pradeep; Seong, Su Hui; Jung, Hyun Ah; Choi, Jae Sue
Title: Characterizing Eckol as a Therapeutic Aid: A Systematic Review Document date: 2019_6_18
ID: 0dpv85od_124
Snippet: In another study, hepatotoxicity in primary rat hepatocytes induced by doxorubicin was used to evaluate the hepatoprotective effects of 14 edible varieties of Korean seaweed. The E. stolonifera isolated phlorotannins dioxinodehydroeckol, eckol, phlorofucofuroeckol-A, dieckol, and triphlorethol A exhibited hepatoprotection with EC 50 values of 3.4, 8.3, 4.4, 5.5, and 11.5 µg/mL, respectively. The importance of molecular weight regarding the hepat.....
Document: In another study, hepatotoxicity in primary rat hepatocytes induced by doxorubicin was used to evaluate the hepatoprotective effects of 14 edible varieties of Korean seaweed. The E. stolonifera isolated phlorotannins dioxinodehydroeckol, eckol, phlorofucofuroeckol-A, dieckol, and triphlorethol A exhibited hepatoprotection with EC 50 values of 3.4, 8.3, 4.4, 5.5, and 11.5 µg/mL, respectively. The importance of molecular weight regarding the hepatoprotective effects against doxorubicin-induced cytotoxicity was explained by the fact that phloroglucinol (molecular weight = 126) having a low molecular weight exhibited no effect, unlike the high molecular weight phlorotannins eckol and dieckol. In conclusion, eckol is suitable as potential therapeutics for the treatment of hepatotoxicity as compared to other evalauted phlorotannins [25] .
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