Author: Manandhar, Bandana; Paudel, Pradeep; Seong, Su Hui; Jung, Hyun Ah; Choi, Jae Sue
Title: Characterizing Eckol as a Therapeutic Aid: A Systematic Review Document date: 2019_6_18
ID: 0dpv85od_130
Snippet: Similarly, in a study related to E. maxima and its crude extract, solvent-soluble fractions, and isolated phlorotannins, the IC 50 values of the solvent soluble fractions ranged from 62.61 to 150.8 µg/mL, with the EtOAc fraction having an excellent inhibitory activity against AChE. Compounds isolated from the EtOAc fraction were identified as phloroglucinol and two of its derivatives, dibenzo-1,4-dioxine 2,4,7,9-tetraol and eckol. Dibenzo-1,4-di.....
Document: Similarly, in a study related to E. maxima and its crude extract, solvent-soluble fractions, and isolated phlorotannins, the IC 50 values of the solvent soluble fractions ranged from 62.61 to 150.8 µg/mL, with the EtOAc fraction having an excellent inhibitory activity against AChE. Compounds isolated from the EtOAc fraction were identified as phloroglucinol and two of its derivatives, dibenzo-1,4-dioxine 2,4,7,9-tetraol and eckol. Dibenzo-1,4-dioxine-2,4,7,9-tetraol (IC 50 84.48 ± 0.26 µM) and eckol (IC 50 76.70 ± 0.35 µM) exhibited better inhibitory activity against AChE than phloroglucinol (IC 50 579.32 ± 0.34 µM), suggesting that dibenzo-1,4-dioxine-2,4,7,9-tetraol and eckol could be effective as AChE inhibitors in treatment of AD [26] .
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